Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a
wealth of biological processes, including ciliary beating, cell division and intracellular …

Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

The glucocorticoid receptor is a known regulator of a variety of physiological processes. Its
mode of action is well defined: upon hormone binding, it undergoes a conformational …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

Hsp90 chaperones receive much attention due to their role in cancer and other pathological
conditions, and a tremendous effort of many laboratories has contributed in the past …

Abstract A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradleto-
grave'system for regulating the steroid binding, trafficking and turnover of the glucocorticoid …

Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …

Recent studies have shown that the microtubule-stabilizing drug paclitaxel, which is
commonly used for the treatment of prostate cancer, inhibits signaling from the androgen …

HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …