Phosphoinositides are a biologically essential class of phospholipids that contribute to
organelle membrane identity, modulate membrane trafficking pathways, and are central …

Virulence in pathogenic protozoa is often tied to secretory processes such as the expression
of adhesins on parasite surfaces or the secretion of proteases to assisted in tissue invasion …

Phenotypic cell-based screens are critical tools for discovering candidate drugs for
development, yet identification of the cellular target and mode of action of a candidate drug …

Intracellular pathogens manipulate host cells to survive and thrive. Cellular sensing and
signaling pathways are among the key host machineries deregulated to favor infection. In …

Adenylate kinases (ADKs) are one of the important enzymes regulating adenosine
triphosphate (ATP) metabolism in Echinococcus granulosus sensu lato. The objective of the …

Phenotypic cell-based screens are critical tools for discovering candidate drugs for
development, yet identification of the cellular target and mode of action of a candidate drug …

Phenotypic cell-based screens are critical to the discovery of new antimalarial lead
compounds. However, identification and validation of cellular targets of lead compounds is …

The endomembrane system is one of the hallmark features of all eukaryotes that
distinguishes them from prokaryotes. Compared to bacteria and archaea, eukaryotic cells …