Activity‐based protein profiling (ABPP) has matured into a standard method for the fast,
sensitive, and selective identification of enzyme activity and inhibitors in proteomes. By …

The development of matrix metalloproteinase (MMP) inhibitors has often been frustrated by
a lack of specificity and subsequent off-target effects. More recently, inhibitor design has …

Protein kinases (PKs) play an important role in the development and progression of cancer
by regulating cell growth, survival, invasion, metastasis, and angiogenesis. Dasatinib (BMS …

During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …

Two-photon fluorescence microscopy (TPFM) provides key advantages over conventional
fluorescence imaging techniques, namely, increased penetration depth, lower tissue …

Fluorescence imaging provides an indispensable way to locate and monitor biological
targets within complex and dynamic intracellular environments. Of the various imaging …

Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound
zinc-dependent endopeptidases that have the combined capacity to degrade all the …

A major translational challenge in the fields of therapeutic angiogenesis and regenerative
medicine is the need to create functional microvasculature. The purpose of this study was to …

Matrix metalloproteinases (MMPs) have long been implicated for roles in cancer initiation,
tumor growth, and metastasis. However, pancreatic cancer clinical trials using broad-based …

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I
transmembrane metalloproteinase involved in pericellular proteolysis, migration and …