Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple
roles in the normal immune response to infection. MMPs facilitate leucocyte recruitment …

Background and Purpose Praziquantel is a schistosomicide, which has been used for more
than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that …

Background Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3,
6, 7, 11b-hexahydro-4H-pyrazino {2, 1-a}-isoquinoline-4-one), and is currently the drug of …

The disease manifestations of schistosomiasis arise from the mammalian host-mediated
type 2 T-helper cell-induced (Th2) fibro-granulomatous inflammatory response to eggs …

Pulmonary fibrosis is a chronic condition characterized by fibroblast proliferation, and the
infiltration of inflammatory cells that can initiate local tissue hypoxia. In this study the effect of …

Schistosomiasis is a widespread parasitic infection that affects humans, as well as wild and
domestic animals. It ranks second after malaria, with a significant health and socio-economic …

J. Neurochem.(2011) 119, 1029–1040. Abstract Diabetes is a major risk factor of stroke and
is associated with increased frequency of stroke and a poorer prognosis for recovery. In …

Tissue fibrosis underlies the majority of human mortality to date with close to half of all
reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and …

The natural world with a large number of terrestrial and marine plants and lower organisms
is a great source of bioactive compounds historically used as remedies in various diseases …