Recombinant adeno-associated viral (rAAV) vectors are considered promising tools for gene
therapy directed at the liver. Whereas rAAV is thought to be an episomal vector, its single …

Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs)
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …

Background Integration site (IS) analysis is a fundamental analytical platform for evaluating
the safety and efficacy of viral vector based preclinical and clinical Gene Therapy (GT). A …

Viral vector characterization and analysis are important components for the development of
safe gene therapeutic products, elucidating the potential genotoxic and immunogenic effects …

High-throughput clonal tracking in patients under hematopoietic stem cell gene therapy with
integrating vector is instrumental in assessing bio-safety and efficacy. Monitoring the fate of …

Recombinant adeno associated virus (rAAV) are gene therapy vectors that do not need to
integrate into the host cell genome to produce their gene product and are classified as …

Machine learning algorithms (MLAs) have recently been applied to predict gene mutations
of Escherichia coli (E. coli) under different exposure conditions, with room for improvement …