Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

The advancements of information technology and related processing techniques have
created a fertile base for progress in many scientific fields and industries. In the fields of drug …

Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global
pathogen with limited treatment options. No new antibiotic chemical class with activity …

By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …

Modern drug discovery approaches often use high-content imaging to systematically study
the effect on cells of large libraries of chemical compounds. By automatically screening …

3D printing (3DP) is a progressive technology capable of transforming pharmaceutical
development. However, despite its promising advantages, its transition into clinical settings …

This work demonstrates and guides how to use a range of state-of-the-art artificial neural-
networks to analyse bacterial microscopy images using the recently developed …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

Recent literature suggests that the fields of machine learning (ML) and high-throughput
experimentation (HTE) have separately received considerable attention from chemists and …

Highlights•Artificial intelligence can combat AMR by discovering antibiotic alternatives.•AI is
fast, cost-efficient, minimum labour dependant strategy.•The chances of failure in AI based …