High-resolution human KIR genotyping
J Downing, L D'Orsogna - Immunogenetics, 2022 - Springer
Killer immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through
interactions with various ligands on the surface of cells, thereby determining whether natural …
interactions with various ligands on the surface of cells, thereby determining whether natural …
Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data
Killer cell immunoglobulin like receptor (KIR) genes and human leukocyte antigen (HLA)
genes play important roles in innate and adaptive immunity. They are highly polymorphic …
genes play important roles in innate and adaptive immunity. They are highly polymorphic …
KIR-HLA interactions extend human CD8+ T cell lifespan in vivo
Y Zhang, AWC Yan, L Boelen… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND There is increasing evidence, in transgenic mice and in vitro, that inhibitory
killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses …
killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses …
Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health
NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis
V Peris Sempere, G Luo, S Muñiz-Castrillo… - Frontiers in …, 2024 - frontiersin.org
Introduction Genetic predisposition to autoimmune encephalitis with antibodies against N-
methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of …
methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of …
Genetic complexity of killer-cell immunoglobulin-like receptor genes in human pangenome assemblies
TK Hung, WC Liu, SK Lai, HW Chuang… - Genome …, 2024 - genome.cshlp.org
The killer-cell immunoglobulin-like receptor (KIR) gene complex, a highly polymorphic
region of the human genome that encodes proteins involved in immune responses, poses …
region of the human genome that encodes proteins involved in immune responses, poses …
High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity
LM Amorim, DG Augusto, N Nemat-Gorgani… - Frontiers in …, 2021 - frontiersin.org
The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural
variation and high sequence similarity among genes, imposing technical difficulties for …
variation and high sequence similarity among genes, imposing technical difficulties for …
[HTML][HTML] An immunogenetic view of COVID-19
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary
approach. In this context, integrating knowledge of immune function with an understanding …
approach. In this context, integrating knowledge of immune function with an understanding …
Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region
L de Brito Vargas, MH Beltrame, B Ho… - Molecular biology …, 2022 - academic.oup.com
The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
(HLA) molecules to regulate the cytotoxic and inflammatory responses of natural killer cells …
[HTML][HTML] An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania
Genetic variation in host immunity impacts the disproportionate burden of infectious
diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte …
diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte …