Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Although protein synthesis dynamics has been studied both with theoretical models and by
profiling ribosome footprints, the determinants of ribosome flux along open reading frames …

In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …

ABSTRACT Introduction: Extracellular vesicles (EVs) represent an important mode of
intercellular communication. There is now a growing awareness that predominant EV …

Highlights•Lipoylation is a rare, but highly conserved lysine posttranslational modification.•
Lipoylated metabolic complexes are evolutionarily conserved from bacteria to humans.• …

By mapping the positions of millions of translating ribosomes in the cell, ribosome profiling
(Ribo-seq) has established its role as a powerful tool to study gene expression. Several …