Liver fibrosis and its end-stage disease cirrhosis are major world health problems arising
from chronic injury of the liver by a variety of etiological factors including viruses, alcohol and …

Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi.
The best-known ETP is gliotoxin, which appears to be a virulence factor associated with …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …

Plant-based whole foods provide thousands of bioactive metabolites to the human diet that
reduce the risk of developing chronic diseases. β-Caryophyllene (CAR) is a common …

The increasing knowledge on the mechanisms responsible for hepatic fibrogenesis together
with the introduction of potentially more effective therapeutic strategies for chronic liver …

We have developed a novel model for depleting mouse hepatic stellate cells (HSCs) that
has allowed us to clarify their contributions to hepatic injury and fibrosis. Transgenic (Tg) …

Liver fibrosis and cirrhosis are a major cause of morbidity and mortality worldwide.
Development of the fibrotic scar is an outcome of chronic liver diseases of varying …

Hepatic fibrosis and cirrhosis cause strong human suffering and necessitate a monetary
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …

Background & Aims Hepatic stellate cells (HSCs) that express glial fibrillary acidic protein
(GFAP) are located between the sinusoidal endothelial cells and hepatocytes. HSCs are …

The endogenous cannabinoid anandamide (AEA) is a lipid mediator that blocks proliferation
and induces apoptosis in many cell types. Although AEA levels are elevated in liver fibrosis …