Structural maintenance of chromosomes (SMC) complexes are ubiquitous genome
regulators with a wide range of functions. Among the three types of SMC complexes in …

Smc5 and Smc6, together with the kleisin Nse4, form the heart of the enigmatic and poorly
understood Smc5/6 complex, which is frequently viewed as a cousin of cohesin and …

Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include
cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome …

The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that
represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing …

Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power
a plethora of functions requiring organization and restructuring of eukaryotic chromosomes …

Background & Aims HBV causes hepatocellular carcinoma (HCC). While it was recently
shown that the ability of HBV X protein (HBx) to impair the Smc5/6 (structural maintenance of …

SMC/kleisin complexes form elongated annular structures, which are critical for
chromosome segregation, genome maintenance, and the regulation of gene expression. We …

The post-translational modification of proteins by SUMO is crucial for cellular viability and
mammalian development in part due to the contribution of SUMOylation to genome …

Cohesin facilitates sister chromatid cohesion through the formation of a large ring structure
that encircles DNA. Its function relies on two structural maintenance of chromosomes (Smc) …

The cohesin-and condensin-related SMC5/6 complex has largely been studied in the
context of DNA repair. Nevertheless, SMC5/6 has an undefined essential function even in …