Our recent study demonstrated the critical role of the mesolimbic dopamine (DA) circuit and
its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The …

Dysfunctions of gene transcription and translation in the nociceptive pathways play the
critical role in development and maintenance of chronic pain. Circular RNAs (circRNAs) are …

Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating
nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that …

Despite women representing most of those affected by major depression, preclinical studies
have focused almost exclusively on male subjects, partially due to a lack of ideal animal …

Robust sex difference among humans regarding psychiatry-and pain-related behaviors is
being researched; however, the use of female mice in preclinical research is relatively rare …

Long-term morphine administration leads to tolerance and a gradual reduction in analgesic
potency. Noncoding microRNAs (miRNAs) modulate gene expression in a …

目的比较三种大鼠蛛网膜下腔给药途径的优缺点. 方法将成年雄性SD 大鼠分为3 组,
分别作如下处理: 重复穿刺(1 次/d), 椎板切除置管以及经皮置管. 设空白对照组 …

Animal models and behavioral tests have been used in experimental research for a long
time to increase human knowledge and contribute to finding solutions to the biological and …

OBJECTIVE: To compare 3 commonly used methods for drug delivery via the lumbar spinal
subarachnoid space in rats. METHODS: We compared the effects of 3 methods for drug …

The neuropeptide galanin has wide distribution in the nervous system and has a role in
diverse functions, such as pain modulation and behavioral responses to stress. A major …