Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator,
a process known as chromosome congression. Centromere-associated protein E (CENP …

For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …

Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and
cellular processes. For instance, microtubules for the support structures for extended …

In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The
best-understood type of partitioning (par) locus encodes an actin homolog called ParM …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers
and harness microtubule dynamics to drive chromosome movement. In budding yeast, the …

Cytoskeleton assembly is instrumental in the regulation of biological functions by physical
forces. In a number of key cellular processes, actin filaments elongated by formins such as …