How cancer hijacks the body's homeostasis through the neuroendocrine system

RM Slominski, C Raman, JY Chen, AT Slominski - Trends in neurosciences, 2023 - cell.com
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Biological effects of CYP11A1-derived vitamin D and lumisterol metabolites in the skin

AT Slominski, TK Kim, Z Janjetovic… - Journal of Investigative …, 2024 - Elsevier
Novel pathways of vitamin D3, lumisterol 3 (L3), and tachysterol 3 (T3) activation have been
discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3. The resulting …

Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system

RM Slominski, JY Chen, C Raman… - Proceedings of the …, 2024 - National Acad Sciences
Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as
cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of …

Recent advances and progress on melanin: from source to application

L Guo, W Li, Z Gu, L Wang, L Guo, S Ma, C Li… - International journal of …, 2023 - mdpi.com
Melanin is a biological pigment formed by indoles and phenolic compounds. It is widely
found in living organisms and has a variety of unique properties. Due to its diverse …

Molecular mechanisms of neurogenic inflammation of the skin

L Marek-Jozefowicz, B Nedoszytko… - International Journal of …, 2023 - mdpi.com
The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …

Research progress on skin aging and active ingredients

X He, F Wan, W Su, W Xie - Molecules, 2023 - mdpi.com
With the advancement of living standards in modern society and the emergence of an aging
population, an increasing number of people are becoming interested in the topic of aging …

Environmental air pollutants affecting skin functions with systemic implications

G Bocheva, RM Slominski, AT Slominski - International Journal of …, 2023 - mdpi.com
The increase in air pollution worldwide represents an environmental risk factor that has
global implications for the health of humans worldwide. The skin of billions of people is …

Dual action of curcumin as an anti-and pro-oxidant from a biophysical perspective

A Wolnicka-Glubisz, A Wisniewska-Becker - Antioxidants, 2023 - mdpi.com
Curcumin, a natural polyphenol widely used as a spice, colorant and food additive, has
been shown to have therapeutic effects against different disorders, mostly due to its anti …

Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota

W Li, Z Wang, J Cao, Y Dong… - Journal of Pineal …, 2023 - Wiley Online Library
It is widely known that lack of sleep damages the skin. Therefore, it is necessary to explore
the relationship between sleep deprivation and skin damage and to find effective treatments …

Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices

S Nishikori, J Yasuda, K Murata, J Takegaki… - Scientific reports, 2023 - nature.com
Aerobic training (AT) is suggested to be an effective anti-aging strategy for skin aging.
However, the respective effects of resistance training (RT) have not been studied. Therefore …