Galectins are glycan-binding proteins that contain one or two carbohydrate domains and
mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal …

Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …

The progression of pancreatic oncogenesis requires immune-suppressive inflammation in
cooperation with oncogenic mutations. However, the drivers of intratumoral immune …

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor
immunity. Here, we identified a unique phenotype of exhausted T cells in mice with …

The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Colorectal cancer is the second leading cause of cancer-related mortality in the United
States. Therapeutic developments in the past decade have extended life expectancy in …

Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

Introduction Galectin-9 (Gal-9) induces adhesion and aggregation of certain cell types and
inhibits the metastasis of tumor cells. T-cell immunoglobulin–and mucin domain-3 …

Over the past few decades, advances in immunological knowledge have led to the
identification of novel immune checkpoints, reinvigorating cancer immunotherapy …

In recent years, an important role has emerged for the glycan‐binding protein Galectin‐9
(Gal‐9) in health and disease. In normal physiology, Gal‐9 seems to be a pivotal modulator …