Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the
predominant excitatory neurotransmitter in the adult mammalian brain; thus, much of past …

The mammalian brain is one of the organs with the highest energy demands, and
mitochondria are key determinants of its functions. Here we show that the type-1 …

Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to
pharmacological tolerance and receptor desensitization in the nervous system. We found …

CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they
endogenously‐produced, plant‐derived or synthetic. These receptors are expressed by …