Protein misfolding diseases are caused by the difficulty of a protein to attain or stably
maintain its native three-dimensional structure. In 2011, the first small molecule that …

The aggregation pathway of transthyretin (TTR) proceeds through rate-limiting dissociation
of the tetramer (a dimer of dimers) and partial misfolding of the resulting monomer, which …

Amyloid fibrils of transthyretin (TTR) consist of full‐length TTR and C‐terminal fragments
starting near residue 50. However, the molecular mechanism underlying the production of …

Misfolding and aggregation of transthyretin are implicated in the fatal systemic disease
known as transthyretin amyloidosis. Here, we report the development of a naringenin …

The aggregation pathway of transthyretin (TTR) proceeds through rate-limiting dissociation
of the tetramer and partial misfolding of the monomers, which assemble into amyloid …

Hereditary transthyretin amyloidosis (ATTR) is an autosomal dominant disease
characterized by the extracellular deposition of the transport protein transthyretin (TTR) as …

Background Studies on antigenic proteins for arboviruses are important for providing
diagnostics and vaccine development. India and its neighboring countries have a huge …

In the present study, we aimed to formulate an effective therapeutic candidate against V30M
mutant transthyretin (TTR) protein to hinder its pathogenic misfolding. Nicotiana alata …

Transthyretin (TTR) is a cerebrospinal fluid and plasma prevalent protein implicated in
heritable and sporadic amyloidosis. Numerous mutations and a wide range of phenotypes …

Purpose: To describe the OCT/A findings, surgical findings and outcomes of vitrectomy
among 8 eyes of 4 patients with vitreoretinal amyloidosis. Participants: Eight eyes of 4 Asian …