Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Age is the primary risk factor for many common human diseases. Here, we quantify the
relative contributions of genetics and aging to gene expression patterns across 27 tissues …

Understanding the consequences of individual transcriptome variation is fundamental to
deciphering human biology and disease. We implement a statistical framework to quantify …

The human genome is capable of producing hundreds of thousands of different proteins and
non‐coding RNAs from< 20 000 genes, in a co‐ordinated and regulated fashion. This is …

Alternative RNA splicing is a key step in gene expression that allows generation of
numerous messenger RNA transcripts encoding proteins of varied functions from the same …

DNA damage has long been advocated as a molecular driver of aging. DNA damage occurs
in a stochastic manner, and is therefore more likely to accumulate in longer genes. The …

Zygotic genome activation (ZGA) is a universal process in early embryogenesis of
metazoan, when the quiescent zygotic nucleus initiates global transcription. However, the …

The risks of heart diseases are significantly modulated by age and sex, but how these
factors influence baseline cardiac gene expression remains incompletely understood. Here …