Erythropoiesis is a highly regulated process where sequential events ensure the proper
differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs) …

Macrophages tightly control the production and clearance of red blood cells (RBC). During
steady state hematopoiesis, approximately 1010 RBC are produced per hour within …

Erythroblastic islands, the specialized niches in which erythroid precursors proliferate,
differentiate, and enucleate, were first described 50 years ago by analysis of transmission …

In this review, we overview the main features and functions of NK cells, focusing on their role
in cell-mediated immune response to tumor cells. In parallel, we discuss the information …

Although proteases of the caspase family are essential mediators of apoptosis in nucleated
cells, in anucleate cells their presence and potential functions are almost completely …

Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family
ligand, sparked a torrent of research, following an initial observation that it could kill tumour …

Circumstantial evidence has implicated tumor necrosis factor α (TNF-α) in the pathogenesis
of anemia of chronic disease (ACD) in rheumatoid arthritis (RA). We investigated the role of …

The therapeutic and preventive activities of retinoids in cancer are due to their ability to
modulate the growth, differentiation, and survival or apoptosis of cancer cells. Here we show …

Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new
erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes …

Highlights•Stress erythropoiesis is a complex response to anemic stress.•Increased steady-
state erythropoiesis is driven by Epo.•Inflammation impairs steady-state erythropoiesis and …