Association of prenatal exposure to valproate and other antiepileptic drugs with risk for attention-deficit/hyperactivity disorder in offspring

J Christensen, L Pedersen, Y Sun, JW Dreier… - JAMA network …, 2019 - jamanetwork.com
Importance Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and
many other neurological and psychiatric disorders. Its use in pregnancy is associated with …

Investigating the use of machine learning models to understand the drugs permeability across placenta

V Chandrasekar, MY Ansari, AV Singh, S Uddin… - IEEE …, 2023 - ieeexplore.ieee.org
Owing to limited drug testing possibilities in pregnant population, the development of
computational algorithms is crucial to predict the fate of drugs in the placental barrier; it …

Prevalence of systemic antibacterial use during pregnancy worldwide: A systematic review

FS Guimarães, TS Dal-Pizzol, MPT Silveira… - Plos one, 2024 - journals.plos.org
Objectives In this study, we aimed to systematically review the literature of the prevalence of
systemic antibacterial use during pregnancy and to perform a descriptive analysis focused …

Reduce, reinforce, and replenish: safeguarding the early-life microbiota to reduce intergenerational health disparities

DLY Dai, C Petersen, SE Turvey - Frontiers in Public Health, 2024 - frontiersin.org
Socioeconomic (SE) disparity and health inequity are closely intertwined and associated
with cross-generational increases in the rates of multiple chronic non-communicable …

Association of prenatal exposure to valproate and other antiepileptic drugs with intellectual disability and delayed childhood milestones

CA Daugaard, L Pedersen, Y Sun, JW Dreier… - JAMA network …, 2020 - jamanetwork.com
Importance There is concern about neurodevelopmental outcomes associated with prenatal
exposure to valproate and other antiepileptic drugs (AEDs) among children of mothers with …

Patterns of prescription medication use during the first trimester of pregnancy in the United States, 1997–2018

MM Werler, SM Kerr, EC Ailes… - Clinical …, 2023 - Wiley Online Library
The objective of this analysis was to describe patterns of prescription medication use during
pregnancy, including secular trends, with consideration of indication, and distributions of use …

Integration of placental transfer in a fetal–maternal physiologically based pharmacokinetic model to characterize acetaminophen exposure and metabolic clearance in …

P Mian, K Allegaert, S Conings, P Annaert… - Clinical …, 2020 - Springer
Abstract Background and Objective Although acetaminophen is frequently used during
pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen …

Interaction between maternal immune activation and antibiotic use during pregnancy and child risk of autism spectrum disorder

C Holingue, M Brucato, C Ladd‐Acosta… - Autism …, 2020 - Wiley Online Library
Prenatal exposure to maternal immune activation (MIA) has been implicated as a risk factor
for the development of autism spectrum disorder (ASD), though the conditions under which …

Quantification of selection bias in studies of risk factors for birth defects among livebirths

D Heinke, JW Rich‐Edwards… - Paediatric and …, 2020 - Wiley Online Library
Background Risk factors for birth defects are frequently investigated using data limited to
liveborn infants. By conditioning on survival, results of such studies may be distorted by …

Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study

CJ Petry, KK Ong, K Beardsall, IA Hughes… - BMC pregnancy and …, 2018 - Springer
Background Low birth weight has important short-and long-term health implications.
Previously it has been shown that pregnancies affected by hyperemesis gravidarum in the …