▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to
the evolution of species and to the origins of human diseases. Here we review our current …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

Xeroderma pigmentosum variant (XP‐V) represents one of the most common forms of this
cancer‐prone DNA repair syndrome. Unlike classical XP cells, XP‐V cells are normal in …

Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of
enzymes required to perform multi-step repair processes. X-ray cross complementing group …

The mechanisms by which imbalanced dNTPs induce mutations have been well
characterized within a test tube, but not in vivo. We have examined mechanisms by which …

DNA and DNA precursors (deoxyribonucleotides) suffer damage by reactive
oxygen/nitrogen species. They are important mutagens for organisms, due to their …

The Escherichia coli protein DinB is a newly identified error-prone DNA polymerase.
Recently, a human homolog of DinB was identified and named DINB1. We report that the …

The DNA repair pathway termed base excision Ž. repair BER purifies genomic DNA of
damaged nucleotides and abasic sites arising from a variety of wx exogenous and …

Mammalian DNA polymerase κ (pol κ), a member of the UmuC/DinB nucleotidyl transferase
superfamily, has been implicated in spontaneous mutagenesis. Here we show that human …