Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …

Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …