Herpesviruses are characterized by their ability to maintain life-long latent infections in their
animal hosts. However, the mechanisms that allow establishment and maintenance of the …

Mature virions of herpes simplex virus type 1 contain an activating factor that primes
transcription from the five virally encoded immediate early (IE) genes. This activator is …

Using Vero cells transformed with the wild-type gene for ICP4 as the permissive host cell, we
isolated herpes simplex virus type 1 (HSV-1) mutants containing deletions in both copies of …

Recurrent herpes simplex virus type 1 (HSV-1) disease usually results from reactivation of
latent virus in sensory neurons and transmission to peripheral sites. Therefore, defining the …

Viral infection is sometimes associated with the initiation or exacerbation of autoimmune
disease, although the underlying mechanisms remain unclear. One proposed mechanism is …

Herpes simplex virus (HSV) encodes a ribonucleotide reductase consisting of two subunits
(140 and 38 kilodaltons) whose genes map to coordinates 0.56 to 0.60 on the viral genome …

A glycoprotein encoded by the UL1 gene of herpes simplex virus type 1 (HSV-1) was
detected in infected cells with antipeptide sera. The UL1 gene has previously been …

We have generated and characterized a deletion mutant of herpes simplex virus type-1,
dlLAT1. 8, which lacks the putative promoter region, transcriptional start site, and 1,015 base …

The five immediate-early genes of herpes simplex virus are expressed during the initial
stages of the infectious cycle, and certain immediate-early proteins have been shown to play …

The herpes simplex viral DNA-binding protein, ICP8, is targeted to two different locations in
the cell nucleus as part of its maturation pathway. Prior to viral DNA synthesis ICP8 was …