The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

▪ Abstract Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are
maintained at low levels by regulated production and efficient removal of these thiols. The …

Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

DNA methylation changes could provide a mechanism for DNA plasticity and dynamism for
short‐term adaptation, enabling a type of cell memory to register cellular history under …

In this report, we demonstrate that valproic acid (VPA), a drug that has been used for
decades in the treatment of epilepsy and as a mood stabilizer, triggers replication …

Metals are ubiquitous and play a critical role in neurobiology. Transition metals are
important because they alter the redox state of the physical environment. Biologically …

Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Objective: To investigate the frequency of neonatal and later childhood morbidity in children
exposed to antiepileptic drugs in utero. Design: Retrospective population based study …

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances
made during the last 10-15 years in fields such as developmental biology, molecular …