Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …
The red blood cell—inflammation vicious circle in sickle cell disease
E Nader, M Romana, P Connes - Frontiers in immunology, 2020 - frontiersin.org
Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …
The worst things in life are free: the role of free heme in sickle cell disease
OT Gbotosho, MG Kapetanaki, GJ Kato - Frontiers in immunology, 2021 - frontiersin.org
Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …
Haptoglobin: From hemoglobin scavenging to human health
A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …
Sickle cell disease: role of oxidative stress and antioxidant therapy
R Vona, NM Sposi, L Mattia, L Gambardella, E Straface… - Antioxidants, 2021 - mdpi.com
Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …
which affects approximately a million people worldwide. It is characterized by a single …
Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
MW Henderson, F Lima, CRP Moraes, A Ilich… - Blood …, 2022 - ashpublications.org
Coagulation activation is a prominent feature of severe acute respiratory syndrome
coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway …
coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway …
Plasma microparticles of sickle patients during crisis or taking hydroxyurea modify endothelium inflammatory properties
Y Garnier, S Ferdinand, M Garnier… - Blood, The Journal …, 2020 - ashpublications.org
Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS),
detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several …
detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several …
Extracellular vesicles in sickle cell disease: Plasma concentration, blood cell types origin distribution and biological properties
Prototype of monogenic disorder, sickle cell disease (SCD) is caused by a unique single
mutation in the β-globin gene, leading to the production of the abnormal hemoglobin S …
mutation in the β-globin gene, leading to the production of the abnormal hemoglobin S …
Extracellular vesicles from thalassemia patients carry iron-containing ferritin and hemichrome that promote cardiac cell proliferation
A Atipimonpat, P Siwaponanan, A Khuhapinant… - Annals of …, 2021 - Springer
Extracellular vesicles (EVs) are bioactive, submicron-sized membrane vesicles released
from all cell types upon activation or apoptosis. EVs including microparticles (MPs) and …
from all cell types upon activation or apoptosis. EVs including microparticles (MPs) and …
Deciphering the relationship between free and vesicular hemoglobin in stored red blood cell units
VL Tzounakas, AT Anastasiadi, ME Lekka… - Frontiers in …, 2022 - frontiersin.org
Red blood cells (RBCs) release hemoglobin (Hb)-containing extracellular vesicles (EVs)
throughout their lifespan in the circulation, and especially during senescence, by spleen …
throughout their lifespan in the circulation, and especially during senescence, by spleen …