Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Conspectus Foldamers have defined and predictable structures, improved resistance to
proteolytic degradation, enhanced chemical diversity, and are versatile in their mimicry of …

Peptides can be developed as effective antagonists of protein–protein interactions, but
conventional peptides (ie, oligomers of l-α-amino acids) suffer from significant limitations in …

Protein–protein interactions (PPI) are vital in modulating biochemical pathways in many
biological processes. Inhibiting PPI is a tremendously important diagnostic and therapeutic …

The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–
protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be …

Highlights•Peptidic foldamers can display improved properties over natural peptides in
vivo.•Designed d-peptides and α/β-peptides can target irregularly-shaped protein …

As a major class of foldamers, aromatic oligoamide foldamers have attracted intense
interest. The rigidity of aromatic residues and amide linkages allows the development of …

Peptides and peptidomimetics represent the middle space between small molecules and
large proteins—they retain the relatively small size and synthetic accessibility of small …

Introduction: Protein-protein interactions are predominant in the workings of all cells. Until
now, there have been a few successes in targeting protein-protein interactions with small …