Triazole hybrid compounds: A new frontier in malaria treatment
Reviewing the advancements in malaria treatment, the emergence of triazole hybrid
compounds stands out as a groundbreaking development. Combining the advantages of …
compounds stands out as a groundbreaking development. Combining the advantages of …
A quinquennial review on recent advancements and developments in search of anti-malarial agents
TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - benthamdirect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …
estimated to kill between one and two million people (mainly children) every year. Novel anti …
Synthesis, spectral characterization of pyrazole derived Schiff base analogs: molecular dynamic simulation, antibacterial and DNA binding studies
We have synthesized the pyrazole-bearing Schiff base derivatives (5a–5e) and (6a–6h) then
the structural confirmation was supported by various spectral analyses. The antibacterial …
the structural confirmation was supported by various spectral analyses. The antibacterial …
Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …
pose a challenge to control the disease. The indiscriminate exploitation of the available …
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates
The persistence of drug resistance poses a significant obstacle to the advancement of
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …
Identification and structure–activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
In an effort to develop a potent anti-malarial agent against Plasmodium falciparum, a
structure-guided virtual screening using an in-house library comprising 652 compounds was …
structure-guided virtual screening using an in-house library comprising 652 compounds was …
Target-based virtual screening of natural compounds identifies a potent antimalarial with selective falcipain-2 inhibitory activity
A Uddin, S Gupta, T Mohammad, D Shahi… - Frontiers in …, 2022 - frontiersin.org
We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …
to find potential hits from the ZINC database of natural compounds against cysteine …
Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors
The rapid emergence of resistance to existing frontline antimalarial drugs emphasizes a
need for the development of target-oriented molecules with novel modes of action. Given the …
need for the development of target-oriented molecules with novel modes of action. Given the …
Synthesis of 1, 2, 4‐Oxadiazole‐sulfonamide Conjugates and Their Synergistic Effect with Ampicillin as Antimicrobial Agents
In this investigation, we synthesized substituted 1, 2, 4‐oxadiazole‐sulfonamide conjugates
(8 a–8 l) through a multistep synthetic approach. These compounds were then evaluated …
(8 a–8 l) through a multistep synthetic approach. These compounds were then evaluated …
Is structural hybridization invoking new dimensions for antimalarial drug discovery research?
B Sharma, A Agarwal, SK Awasthi - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Despite effective prevention methods, malaria is a devastating, persistent infection caused
by protozoal parasites that result in nearly half a million fatalities annually. Any progress …
by protozoal parasites that result in nearly half a million fatalities annually. Any progress …