Here, there, and everywhere: The importance of ER membrane contact sites
H Wu, P Carvalho, GK Voeltz - Science, 2018 - science.org
BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …
[HTML][HTML] Intracellular Ca2+ sensing: its role in calcium homeostasis and signaling
R Bagur, G Hajnóczky - Molecular cell, 2017 - cell.com
Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …
become toxic and cause cell death. Selective control of specific targets depends on …
Coming together to define membrane contact sites
Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …
recently a specific field dealing with organelle communication at membrane contact sites …
Endoplasmic reticulum–plasma membrane contact sites
Y Saheki, P De Camilli - Annual review of biochemistry, 2017 - annualreviews.org
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …
direct physical contacts with all other classes of membranous organelles, including the …
Phosphoinositides in control of membrane dynamics
KO Schink, KW Tan, H Stenmark - Annual review of cell and …, 2016 - annualreviews.org
Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …
Control of plasma membrane lipid homeostasis by the extended synaptotagmins
Acute metabolic changes in plasma membrane (PM) lipids, such as those mediating
signalling reactions, are rapidly compensated by homeostatic responses whose molecular …
signalling reactions, are rapidly compensated by homeostatic responses whose molecular …
The ER stress sensor PERK coordinates ER-plasma membrane contact site formation through interaction with filamin-A and F-actin remodeling
AR van Vliet, F Giordano, S Gerlo, I Segura… - Molecular cell, 2017 - cell.com
Loss of ER Ca 2+ homeostasis triggers endoplasmic reticulum (ER) stress and drives ER-
PM contact sites formation in order to refill ER-luminal Ca 2+. Recent studies suggest that …
PM contact sites formation in order to refill ER-luminal Ca 2+. Recent studies suggest that …
ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P2) and regulate its level at the plasma membrane
ORP5 and ORP8, members of the oxysterol-binding protein (OSBP)-related proteins (ORP)
family, are endoplasmic reticulum membrane proteins implicated in lipid trafficking. ORP5 …
family, are endoplasmic reticulum membrane proteins implicated in lipid trafficking. ORP5 …
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
WM Yeshaw, M van der Zwaag, F Pinto, LL Lahaye… - Elife, 2019 - elifesciences.org
The VPS13A gene is associated with the neurodegenerative disorder Chorea
Acanthocytosis. It is unknown what the consequences are of impaired function of VPS13A at …
Acanthocytosis. It is unknown what the consequences are of impaired function of VPS13A at …
PERK recruits E-Syt1 at ER–mitochondria contacts for mitochondrial lipid transport and respiration
ML Sassano, AR van Vliet, E Vervoort… - Journal of Cell …, 2023 - rupress.org
The integrity of ER–mitochondria appositions ensures transfer of ions and phospholipids
(PLs) between these organelles and exerts crucial effects on mitochondrial bioenergetics …
(PLs) between these organelles and exerts crucial effects on mitochondrial bioenergetics …