For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

The human brain is a uniquely complex organ, which has evolved a sophisticated protection
system to prevent injury from external insults and toxins. Designing molecules that can …

Simple Summary Glioblastoma multiforme (GBM) are among the most lethal tumors. The
highly invasive nature and presence of GBM stem cells, as well as the blood brain barrier …

Effective treatments for primary brain tumors and brain metastases represent a major unmet
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …

Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …

With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a
vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …