Background Influenza vaccines require annual readministration; however, several reports
have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We …

H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that
abrogate binding of human antibodies. During the 2014–2015 influenza season, clade 3C …

Seasonal influenza vaccines prevent influenza-related illnesses, hospitalizations, and
deaths. However, these vaccines are not as effective as other viral vaccines, and there is …

The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can
be improved by the use of vaccines with higher antigen content or adjuvants. We conducted …

Prior vaccination can alternately enhance or attenuate influenza vaccine immunogenicity
and effectiveness. Analogously, we found that vaccine immunogenicity was enhanced by …

Abstract Background The H3N2 component of egg-based 2017–2018 influenza vaccines
possessed an adaptive substitution that alters antigenicity. Several influenza vaccines …

Abstract Background In Australia, seasonal inactivated influenza vaccine is typically offered
in April. However, the onset, peak and end of a typical influenza season vary, and optimal …

Healthcare institutions with mandatory influenza vaccination policies have over 90%
vaccination rates among healthcare workers (HCWs) resulting in a population that has …

With concerns about the efficacy of repeat annual influenza vaccination, it is important to
better understand the impact of priming vaccine immunity and develop an effective …

Background Older adults are more vulnerable to seasonal influenza than younger adults.
The immune responses of older persons to the influenza vaccine are usually poorer than …