Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …

Fatty acids are involved in several metabolic processes, including the development of
metabolic and cardiovascular diseases. In recent years a disease that has received …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

The mitochondrial carnitine system plays an obligatory role in β-oxidation of long-chain fatty
acids by catalyzing their transport into the mitochondrial matrix. This transport system …

Competition for respiration between substrates in animal tissues has been known for at least
80 Years. The most important interaction, quantitatively is between glucose and fatty acids …

▪ Abstract Apart from being an important macronutrient, dietary fat has recently gained much
prominence for its role in regulating gene expression. Polyunsaturated fatty acids (PUFAs) …

The control of mitochondrial β-oxidation, including the delivery of acyl moieties from the
plasma membrane to the mitochondrion, is reviewed. Control of β-oxidation flux appears to …

β-Cells possess inherent mechanisms to adapt to overnutrition and the prevailing
concentrations of glucose, fatty acids, and other fuels to maintain glucose homeostasis …

Obesity is typically associated with elevated levels of free fatty acids (FFAs) and is linked to
glucose intolerance and type 2 diabetes. FFAs exert divergent effects on insulin secretion …