Targeted delivery to bone and mineral deposits using bisphosphonate ligands

LE Cole, T Vargo-Gogola, RK Roeder - Advanced drug delivery reviews, 2016 - Elsevier
The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Technetium (I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

GV Sidorenko, AE Miroslavov, MY Tyupina - Coordination Chemistry …, 2023 - Elsevier
Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

X Zhan, L Jia, Y Niu, H Qi, X Chen, Q Zhang, J Zhang… - Biomaterials, 2014 - Elsevier
Tumour-associated macrophages (TAMs) are a set of macrophages residing in the tumour
microenvironment. They play essential roles in mediating tumour angiogenesis, metastasis …

Organometallic complexes for SPECT imaging and/or radionuclide therapy

GR Morais, A Paulo, I Santos - Organometallics, 2012 - ACS Publications
This article reviews Re and Tc organometallic chemistry and radiochemistry, focusing on the
most relevant aspects to design radiotools for molecular imaging and therapy. The review …

In vivo imaging techniques for bone tissue engineering

EA Fragogeorgi, M Rouchota… - Journal of tissue …, 2019 - journals.sagepub.com
Bone is a dynamic tissue that constantly undergoes modeling and remodeling. Bone tissue
engineering relying on the development of novel implant scaffolds for the treatment of pre …

A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines

A Yazdani, H Bilton, A Vito, AR Genady… - Journal of medicinal …, 2016 - ACS Publications
A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-
cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures …

Bisphosphonates as radionuclide carriers for imaging or systemic therapy

E Palma, JDG Correia, MPC Campello… - Molecular …, 2011 - pubs.rsc.org
Bisphosphonates (BP's), biologically stable analogs of naturally occurring pyrophosphates,
became the treatment of choice for pathologic conditions characterized by increased …

Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological materials: An updated review

N Manousi, PD Tzanavaras, CK Zacharis - Journal of Pharmaceutical and …, 2022 - Elsevier
Although almost 60 years have passed since their first application, bisphosphonates are still
in use as medicine against osteoporosis. Due to their chemical structures and properties …

Target-specific Tc (CO) 3-complexes for in vivo imaging

M Morais, A Paulo, L Gano, I Santos… - Journal of Organometallic …, 2013 - Elsevier
In recent years, the remarkable characteristics of the organometallic precursor fac-[M (CO) 3
(H 2 O) 3]+(M= Re, Tc) introduced by Alberto and co-workers brought renewed interest to the …

99mTc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting

AR Genady, D Fong, SR Slikboer… - ACS Applied Nano …, 2020 - ACS Publications
Tailoring carbon nanotube surface chemistry is essential for biomedical applications.
Bisphosphonate–carbon nanotube conjugates were prepared to target regions of active …