Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through
tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety …

Fibroblast growth factor-23 (FGF)-23 is a phosphaturic hormone involved in mineral bone
metabolism that helps control phosphate homeostasis and reduces 1, 25-dihydroxyvitamin …

Elevations in plasma phosphate concentrations (hyperphosphatemia) occur in chronic
kidney disease (CKD), in certain genetic disorders, and following the intake of a phosphate …

Hyperglycemic conditions (HG), at early stages of diabetic nephropathy (DN), cause a
decrease in podocyte numbers and an aberration of their function as key cells for glomerular …

Abstract Purpose of Review Fibroblast growth factor 23 (FGF23) is a key phosphate-
regulating hormone that has been associated with adverse outcomes in patients with …

Fibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by
osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which …

Cardiovascular disease (CVD) is the major cause of death in chronic kidney disease (CKD)
and is associated with high circulating fibroblast growth factor (FGF) 23 levels. It is …

Acute kidney injury is a global disease with high morbidity and mortality. Recent studies
have revealed that the fibroblast growth factor-23—α-Klotho axis is closely related to chronic …

Chronic kidney disease (CKD) is a global health epidemic that significantly increases
mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important …

Osteoporosis and cardiovascular disease represent two significant clinical burdens
worldwide, which have been found to be clinically intertwined. The skeleton is highly …