Solvent-free heterocyclic synthesis

MAP Martins, CP Frizzo, DN Moreira, L Buriol… - Chemical …, 2009 - ACS Publications
Heterocycles form, by far, the largest of the classical divisions of organic chemistry.
Moreover, they are of immense importance not only biologically and industrially but also to …

More sustainable approaches for the synthesis of N-based heterocycles

NR Candeias, LC Branco, PMP Gois… - Chemical …, 2009 - ACS Publications
More Sustainable Approaches for the Synthesis of N-Based Heterocycles | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

The B iginelli Dihydropyrimidine Synthesis

CO Kappe, A Stadler - Organic reactions, 2004 - Wiley Online Library
The cyclocondensation of suitable CH‐acidic carbonyl compounds, aldehydes, and urea‐
type blocks under acidic conditions provides multifunctionalized derivatives. The discovery …

A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

The generation of dihydropyrimidine libraries utilizing Biginelli multicomponent chemistry

CO Kappe - QSAR & combinatorial science, 2003 - Wiley Online Library
With the emergence of high‐throughput screening in the pharmaceutical industry over a
decade ago, synthetic chemists were faced with the challenge of preparing large collections …

Synthesis of dihydropyrimidinones and thiones by multicomponent reactions: strategies beyond the classical Biginelli reaction

JP Wan, Y Liu - Synthesis, 2010 - thieme-connect.com
The three-component Biginelli reaction for the synthesis of dihydropyrimidinone and
corresponding dihydropyrimidinethiones (DHPMs) has been known for more than a century …

Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines

NR Kamdar, DD Haveliwala, PT Mistry… - European journal of …, 2010 - Elsevier
The clinical significance of pyran and pyrimidine condensed systems and the raise in
problem of multidrug resistant bacterial pathogens has directed us to synthesize …

Recyclizations of 3-formylchromones with binucleophiles

AS Plaskon, OO Grygorenko, SV Ryabukhin - Tetrahedron, 2012 - Elsevier
Chromones are widely recognized as an important class of biologically active compounds of
both natural and synthetic origin. 1 e8 The less known but very useful application of the …

Concise synthesis of guanidine-containing heterocycles using the Biginelli reaction

BL Nilsson, LE Overman - The Journal of organic chemistry, 2006 - ACS Publications
Two general methods for the synthesis of 2-imino-5-carboxy-3, 4-dihydropyrimidines were
developed using the three-component Biginelli reaction. The first method utilizes pyrazole …

Greener and Expeditious Synthesis of Fused Six-Membered N,N-Heterocycles Using Microwave Irradiation

N Kaur - Synthetic Communications, 2015 - Taylor & Francis
The development of new strategies for the synthesis of fused heterocycles has remained a
highly attractive but challenging proposition. An overview of the application of microwave …