Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1, 2, 3-triazole substituted 4-hydroxybenzohyrdazide …
In this study, 16 new hybrid compounds 6 (ah) and 7 (ah) were synthesized starting from
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
New Pd (II) complexes of the bisthiocarbohydrazones derived from isatin and disubstituted salicylaldehydes: Synthesis, characterization, crystal structures and …
Abstract Pd (II) complexes (Pd1, Pd2, and Pd3) were synthesized for the first time using
asymmetric isatin bisthiocarbohydrazone ligands and PdCl2 (PPh3) 2. All complexes were …
asymmetric isatin bisthiocarbohydrazone ligands and PdCl2 (PPh3) 2. All complexes were …
New Anthranilic Acid Hydrazones as Fenamate Isosteres: Synthesis, Characterization, Molecular Docking, Dynamics & in Silico ADME, in Vitro Anti‐Inflammatory …
H Şenol, Z Çağman… - Chemistry & …, 2023 - Wiley Online Library
In this study, twenty new anthranilic acid hydrazones 6–9 (a–e) were synthesized and their
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
Novel chalcone derivatives of ursolic acid as acetylcholinesterase inhibitors: Synthesis, characterization, biological activity, ADME prediction, molecular docking and …
Acetylcholinesterase (AChE) is a critical target in the prevention of Alzheimer's Disease (AD)
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
Synthesis, molecular docking and some metabolic enzyme inhibition properties of biphenyl-substituted chalcone derivatives
The new synthesized biphenyl-substituted chalcone derivatives were evaluated against the
human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase …
human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase …
Synthesis, Characterization, Molecular Docking and in vitro Biological Studies of Thiazolidin‐4‐one Derivatives as Anti‐Breast‐Cancer Agents
In this study, 16 new compounds were synthesized starting from methylparaben. These new
compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin‐4‐on …
compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin‐4‐on …
Pentafluorobenzyl-substituted benzimidazolium salts: Synthesis, characterization, crystal structures, computational studies and inhibitory properties of some metabolic …
This work contains the synthesis and characterization of the pentafluorobenzyl-substituted
benzimidazolium salts which N-heterocyclic carbene (NHC) precursors. All compounds …
benzimidazolium salts which N-heterocyclic carbene (NHC) precursors. All compounds …
Exploring enzyme inhibition profiles of novel halogenated chalcone derivatives on some metabolic enzymes: Synthesis, characterization and molecular modeling …
Enzyme inhibition is a very active area of research in drug design and development.
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
Synthesis and Biological Activity of some bromophenols and their derivatives including Natural products
In addition to the first synthesis of the natural bromophenol butyl 2‐(3, 5‐dibromo‐4‐
hydroxyphenyl) acetate (1), indene derivatives 34 and 35 were synthesized from 3 …
hydroxyphenyl) acetate (1), indene derivatives 34 and 35 were synthesized from 3 …