Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Two decades ago a class of ion channels, hitherto unsuspected, was discovered. In
mammals these Transient Receptor Potential channels (TRPs) have not only expanded in …

TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6
inhibitors are needed for the treatment of a broad range of diseases associated with …

Permeabilization of cell membranous structures by nanosecond pulsed electric field (nsPEF)
triggers transient rise of cytosolic Ca2+ concentration ([Ca2+] i), which determines …

Neuronal activity can be modulated by mechanical stimuli. To study this phenomenon
quantitatively, we mechanically stimulated rat cortical neurons by shear stress and local …

Background Lipophagy is an autophagic process, which delivers the intracellular lipid
droplets to the lysosomes for degradation. Recent studies revealed that the impairment of …

Nuclear factor kappa B (NF-κB) is a redox-associated transcription factor that is involved in
the activation of survival pathways. We have previously shown that deoxycholate (DOC) …

The mitochondrial calcium (Ca2+) uniporter (MCU) mediates high-capacity mitochondrial
Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that …

Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile
acids as a focus of this review since high levels of hydrophobic bile acids accompany a …

Background In allergic asthma, exposure to relevant antigens leads to an early asthmatic
response (EAR) followed, in certain subjects, by a late asthmatic response (LAR). Although …