This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …

The endoplasmic reticulum (ER) is an essential organelle involved in many cellular
functions including protein folding and secretion, lipid biosynthesis, and calcium …

The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

Ubiquitin modification of many cellular proteins targets them for proteasomal degradation,
but in addition can also serve non-proteolytic functions. Over the last years, a significant …

In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …

Sophisticated quality control mechanisms prolong retention of protein-folding intermediates
in the endoplasmic reticulum (ER) until maturation while sorting out terminally misfolded …

In order to maintain proper cellular functions, all living cells, from bacteria to mammalian
cells, must carry out a rigorous quality control process in which nascent and newly …