Prevalence of smoldering multiple myeloma based on nationwide screening

S Thorsteinsdóttir, GK Gíslason, T Aspelund… - Nature medicine, 2023 - nature.com
Smoldering multiple myeloma (SMM) is an asymptomatic precursor to multiple myeloma.
Here we define the epidemiological characteristics of SMM in the general population in …

Evaluating early intervention in smoldering myeloma clinical trials: a systematic review

A Kakkilaya, A Trando, ERS Cliff, H Mian… - The …, 2024 - academic.oup.com
Background Smoldering multiple myeloma (SMM), an asymptomatic precursor of multiple
myeloma (MM), carries a variable risk of progression to MM. There is little consensus on the …

How I approach smoldering multiple myeloma

I Vaxman, MA Gertz - Blood, The Journal of the American …, 2022 - ashpublications.org
The current standard of care in smoldering multiple myeloma (SMM) is close surveillance,
outside of clinical trials. Efforts are being made to understand the pathobiologic process that …

Clinician preferences on treatment of smoldering myeloma: a cross-sectional survey

GR Mohyuddin, R Chakraborty, ERS Cliff… - …, 2023 - thelancet.com
Background Smoldering myeloma (SMM) is an asymptomatic precursor condition to multiple
myeloma (MM) with a variable risk of progression. The management of high-risk SMM (HR …

The consultant's guide to smoldering multiple myeloma

S Thorsteinsdottir, SY Kristinsson - Hematology, 2022 - ashpublications.org
Smoldering multiple myeloma (SMM) is an asymptomatic precursor condition to multiple
myeloma (MM). The prevalence of SMM is 0.5% in persons over 40 years old; it is higher in …

Heterogeneity of enrolment criteria for ongoing smouldering myeloma trials.

MA Soomro, J Hoffman, AM Goodman… - British journal of …, 2022 - search.ebscohost.com
Smouldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder
meeting serological and morphological criterion of multiple myeloma (MM) but without …

[HTML][HTML] Monoclonal Antibodies in Smoldering Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance: Current Status and Future Directions

V Ferla, F Farina, T Perini, M Marcatti, F Ciceri - Pharmaceuticals, 2024 - mdpi.com
Monoclonal antibodies (MoAbs) targeting several cellular receptors have significantly
improved the prognosis of multiple myeloma (MM). Their high effectiveness and safety raise …

Survival in smouldering myeloma and symptomatic myeloma: is there an emerging Will Rogers phenomenon?

R Chakraborty - European Journal of Cancer, 2022 - ejcancer.com
The phenomenon of stage migration in cancers leads to apparent survival improvement in
both lower and higher stages. This is due to an upward migration of patients with adverse …

Smoldering multiple myeloma: Reviewing the rationale for intervention

M Gertz - Leukemia & lymphoma, 2022 - Taylor & Francis
Smoldering multiple myeloma has been recognized for over 40 years and represents a pre-
symptomatic phase of the 2nd most common hematologic malignancy. 1/3 of patients will …

Should high risk smoldering myeloma be treated outside a clinical trial: NO

MA Gertz, I Vaxman - Leukemia & Lymphoma, 2021 - Taylor & Francis
In this issue of Leukemia and Lymphoma, Mohyuddin and colleague examined the
characteristics of 32 clinical trials evaluating patients with smoldering multiple myeloma. In …