Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy
J Yao, M Yang, Y Duan - Chemical reviews, 2014 - ACS Publications
2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
Five years of GWAS discovery
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …
experimental design of genome-wide association studies (GWASs). These studies were …
Revisiting the genome-wide significance threshold for common variant GWAS
Over the last decade, GWAS meta-analyses have used a strict P-value threshold of 5× 10− 8
to classify associations as significant. Here, we use our current understanding of frequently …
to classify associations as significant. Here, we use our current understanding of frequently …
Population structure and eigenanalysis
N Patterson, AL Price, D Reich - PLoS genetics, 2006 - journals.plos.org
Current methods for inferring population structure from genetic data do not provide formal
significance tests for population differentiation. We discuss an approach to studying …
significance tests for population differentiation. We discuss an approach to studying …
[图书][B] Handbook of personality: Theory and research
This authoritative handbook is the reference of choice for researchers and students of
personality. Leading authorities describe the most important theoretical approaches in …
personality. Leading authorities describe the most important theoretical approaches in …
Carbon nanotubes as optical biomedical sensors
Biosensors are important tools in biomedical research. Moreover, they are becoming an
essential part of modern healthcare. In the future, biosensor development will become even …
essential part of modern healthcare. In the future, biosensor development will become even …
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated
Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the …
Ca2+ (CRAC) channels, promoting the immune response to pathogens by activating the …
Epigenome-wide association studies for common human diseases
VK Rakyan, TA Down, DJ Balding, S Beck - Nature Reviews Genetics, 2011 - nature.com
Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …
associated with common diseases, a substantial proportion of the causality remains …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …