Natural products as inducers of non-canonical cell death: a weapon against cancer

G Greco, E Catanzaro, C Fimognari - Cancers, 2021 - mdpi.com
Simple Summary Anticancer therapeutic approaches based solely on apoptosis induction
are often unsuccessful due to the activation of resistance mechanisms. The identification …

Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson

Y Sun, AWH Yang, GB Lenon - International journal of molecular sciences, 2020 - mdpi.com
Cnidium monnieri (L.) Cusson (CMC) is a traditional Chinese herbal medicine that has been
widely grown and used in Asia. It is also known as “She chuang zi” in China (Chinese …

Serum cytokine levels in children with spectrum autism disorder: Differences in pro-and anti-inflammatory balance

NK Kordulewska, E Kostyra, K Piskorz-Ogórek… - Journal of …, 2019 - Elsevier
Abstract Background Autism Spectrum Disorders (ASDs) is a developmental and
neurological disorder that affects all aspects of social communication, with limited and …

Modulatory effects of osthole on lipopolysaccharides-induced inflammation in Caco-2 cell monolayer and co-cultures with THP-1 and THP-1-derived macrophages

NK Kordulewska, J Topa, M Tańska, A Cieślińska… - Nutrients, 2020 - mdpi.com
Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they
may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide …

A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole

NK Kordulewska, E Kostyra, B Chwała… - International …, 2019 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by
Diagnosis and Statistic Manual 5 (DSM-5) as persistent social interaction and …

Osthole inhibits expression of genes associated with toll-like receptor 2 signaling pathway in an organotypic 3D skin model of human epidermis with atopic dermatitis

NK Kordulewska, J Topa, R Stryiński, B Jarmołowska - Cells, 2021 - mdpi.com
The Toll-like receptor (TLR) family signature has been linked to the etiopathology of atopic
dermatitis (AD), a chronic inflammatory skin disease associated with skin barrier dysfunction …

Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis

X Hu, Y Zhou, J Shi, M Qi, X Li, Y Yang, C Zhu… - European Journal of …, 2023 - Elsevier
Atopic dermatitis (AD) is the most prevalent chronic inflammatory skin condition and
significantly reduces quality of life. Tight junction (TJ), which is located directly beneath the …

Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES …

NK Kordulewska, E Kostyra, A Cieślińska… - Immunobiology, 2017 - Elsevier
Introduction Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is
assumed as a natural antihistamine alternative. This paper compares results of histamine …

Effects of osthole on inflammatory gene expression and cytokine secretion in histamine-induced inflammation in the caco-2 cell line

NK Kordulewska, J Topa, D Rozmus… - International Journal of …, 2021 - mdpi.com
Hyperactivity of the immune system in the gastrointestinal tract leads to the development of
chronic, inflammation-associated disorders. Such diseases, including inflammatory bowel …

Cytokines concentrations in serum samples from allergic children—Multiple analysis to define biomarkers for better diagnosis of allergic inflammatory process

NK Kordulewska, A Cieślińska, E Fiedorowicz… - Immunobiology, 2018 - Elsevier
Background Allergic diseases can expand at any age as a result of complicated interaction
of environmental and genetic factors. Through the years, studies have found that allergic …