Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a potential therapeutic
target. However, there are conceptual and practical challenges to directly targeting kidney …

Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …

Numerous studies have proven the critical role of macrophages in the renal fibrosis process.
Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has …

Ferroptosis is a newly identified form of regulated cell death characterized by iron
accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of …

Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its
structure and function. However, regulatory mechanisms behind this complex …

Human large-scale genetic association studies have identified sequence variations at
thousands of genetic risk loci that are more common in patients with diverse metabolic …