Purpose Testosterone replacement and associated pharmacologic agents are effective
strategies to treat male hypogonadism; however, nutraceutical agents and lifestyle …

Ageing is the time-dependent gradual decline of the functional characteristics in an
organism. It has been shown that it results in the loss of reproductive health and fertility. The …

The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in
supporting germ cell development and maintaining testicular characteristics and …

China has the world's largest reserves of rare earth elements (REEs), but widespread
mining and application of REEs has led to an increased risk of potential pollution. Yttrium …

Leydig cells of the testis have the capacity to synthesize androgen (mainly testosterone)
from cholesterol. Adult Leydig cells are the cell type for the synthesis of testosterone, which …

Simple Summary Organoids are 3D-cell culture systems composed of tissue-specific cells
that create structures similar to those of their tissue of origin. Organoids have generated …

Casein kinase 1α (CK1α) is a main component of the Wnt/β-catenin signaling pathway,
which participates in multiple biological processes. Our recent study demonstrated that …

Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as
high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause …

Optimal functioning of Sertoli cells is crucial for spermatogenesis which is under tight
regulation of sex hormones, estrogen and androgen. Adult rat Sertoli cells expresses …

Objective We investigated the protective effects of ephedra herb (HEPH) on adriamycin-
induced testicular toxicity in rats and explored the potential mechanisms underlying these …