Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …

Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Dysregulation of sphingomyelin and ceramide metabolism have been implicated in
Alzheimer's disease. Genome-wide and transcriptome-wide association studies have …

Regulated cell death (RCD) is an ordered and tightly orchestrated set of changes/signaling
events in both gene expression and protein activity and is responsible for normal …

The nucleolus has been known for a long time to fulfill crucial functions in ribosome
biogenesis, of which cancer cells can become addicted to in order to produce sufficient …

Alzheimer's disease (AD) is an irreversible age-related neurodegenerative disorder
clinically characterized by severe memory impairment, language deficits and cognitive …

Abstract Down's syndrome (DS), a common chromosomal disease caused by chromosome
21 trisomy, is the main cause of cognitive impairment in children worldwide. Emerging …

Background: Dementia is a neurocognitive disorder associated with the aging brain and
mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and …

Strategies to correct declining nicotinamide adenine dinucleotide (NAD+) levels in
neurological disease and biological ageing are promising therapeutic candidates. These …