Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Natriuretic peptides, which are activated in heart failure, play an important cardioprotective
role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic …

INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …

Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones
produced and released by cardiomyocytes, exerting several systemic effects. Together with …

Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of
a blood vessel in the brain, thereby restricting blood supply to the area in question, and …

Cachexia is associated with poor prognosis in chronic heart failure patients, but the
underlying mechanisms of cachexia triggered disease progression remain poorly …

C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the
natriuretic peptide system (NPS). Specifically, research has established the production of …

Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic
peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to …

Aims C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling
species that governs vascular homoeostasis; CNP is also expressed in the heart but an …