Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4
(H3K4me3) located after first exons and around transcription start sites. This epigenetic mark …

Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

Chronic inflammation promotes epigenetic reprogramming in cancer progression by
pathways that remain unclear. The oncogenic MUC1-C protein is activated by the …

Transcription must be tightly controlled to regulate gene expression and development.
However, our understanding of the molecular mechanisms that influence transcription and …

Myeloid malignancies develop through the accumulation of genetic and epigenetic
alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC …

Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality.
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …

Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers.
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …