The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration

SM LeVine - The Neuroscientist, 2024 - journals.sagepub.com
Chlorosis in azaleas is characterized by an interveinal yellowing of leaves that is typically
caused by a deficiency of iron. This condition is usually due to the inability of cells to …

Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer's Disease

SM LeVine - Cells, 2023 - mdpi.com
The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …

Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress

F Varzideh, SS Jankauskas… - The Journal of …, 2022 - Am Soc Clin Investig
Sortilin is a glycoprotein mainly known for its role as a trafficking molecule directing proteins
to specific secretory or endocytic compartments of the cell. Its actual contribution to essential …

Zebrafish as a model organism for studying pathologic mechanisms of neurodegenerative diseases and other neural disorders

Y Liu - Cellular and Molecular Neurobiology, 2023 - Springer
Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

[HTML][HTML] Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors

E Bagyinszky, SSA An - International Journal of Molecular Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various
genetic factors. In addition to the well-established amyloid precursor protein (APP) …

Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus

Y Wang, Y Yang, Y Cai, A Aobulikasimu… - Advanced …, 2024 - Wiley Online Library
Abstract Sortilin‐related receptor 1 (SorL1) deficiency is a genetic predisposition to familial
Alzheimer's disease (AD), but its pathology is poorly understood. In SorL1‐null rats, a …

[HTML][HTML] Use of zebrafish genetic models to study etiology of the amyloid-beta and neurofibrillary tangle pathways in Alzheimer's disease

K Kiper, JL Freeman - Current Neuropharmacology, 2022 - ncbi.nlm.nih.gov
The prevalence of neurodegenerative diseases is increasing globally, with an imperative
need to identify and expand the availability of pharmaceutical treatment strategies …

Alzheimer's disease and SARS-CoV-2: pathophysiological analysis and social context

GG Ortiz, IE Velázquez-Brizuela, GE Ortiz-Velázquez… - Brain Sciences, 2022 - mdpi.com
The COVID-19 pandemic has proven to be a challenge for healthcare systems, especially in
terms of the care of patients with Alzheimer's disease (AD). Age is one of the major risk …

The use of zebrafish in transcriptome analysis of the early effects of mutations causing early onset familial Alzheimer's disease and other inherited neurodegenerative …

M Lardelli, L Baer, N Hin, A Allen… - Journal of …, 2024 - content.iospress.com
The degree to which non-human animals can be used to model Alzheimer's disease is a
contentious issue, particularly as there is still widespread disagreement regarding the …

Genetic phenotypes of alzheimer's disease: Mechanisms and potential therapy

M Quan, S Cao, Q Wang, S Wang, J Jia - Phenomics, 2023 - Springer
Years of intensive research has brought us extensive knowledge on the genetic and
molecular factors involved in Alzheimer's disease (AD). In addition to the mutations in the …