Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension

AP Tanna, M Johnson - Ophthalmology, 2018 - Elsevier
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Ocular perfusion pressure in glaucoma

VP Costa, A Harris, D Anderson… - Acta …, 2014 - Wiley Online Library
This review article discusses the relationship between ocular perfusion pressure and
glaucoma, including its definition, factors that influence its calculation and epidemiological …

Regional comparisons of optical coherence tomography angiography vessel density in primary open-angle glaucoma

HL Rao, ZS Pradhan, RN Weinreb, HB Reddy… - American journal of …, 2016 - Elsevier
Purpose To compare the diagnostic abilities of the vessel densities in optic nerve head
(ONH), peripapillary, and macular regions measured using optical coherence tomography …

Age-related eye disease and gender

M Zetterberg - Maturitas, 2016 - Elsevier
Worldwide, the prevalence of moderate to severe visual impairment and blindness is 285
millions, with 65% of visually impaired and 82% of all blind people being 50 years and older …

Vascular risk factors in glaucoma: a review

M Yanagi, R Kawasaki, JJ Wang… - Clinical & …, 2011 - Wiley Online Library
Glaucoma, one of the major causes of blindness in the world, is a progressive optic
neuropathy. Elevated intraocular pressure is a well‐known major risk factor for glaucoma. In …

The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease

JM Sivak - Investigative ophthalmology & visual science, 2013 - iovs.arvojournals.org
Alzheimer's disease (AD) is a common, incurable, and progressive dementia, characterized
by loss of learning and memory and the neuropathologic accumulation of amyloid plaques …

Normal‑tension glaucoma: Pathogenesis and genetics

A Trivli, I Koliarakis, C Terzidou… - Experimental and …, 2019 - spandidos-publications.com
Normal‑tension glaucoma (NTG) is a multifactorial optic neuropathy which, similar to open‑
angle glaucomas, is characterized by progressive retinal ganglion cell death and …

Energy metabolism in the inner retina in health and glaucoma

H Liu, V Prokosch - International journal of molecular sciences, 2021 - mdpi.com
Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of
diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons …

Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma

S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …

Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye

A Monavarfeshani, W Yan, C Pappas… - Proceedings of the …, 2023 - National Acad Sciences
Although the visual system extends through the brain, most vision loss originates from
defects in the eye. Its central element is the neural retina, which senses light, processes …