Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Retinal ganglion cells (RGCs), the projection neurons of the eye, cannot regenerate their
axons once the optic nerve has been injured and soon begin to die. Whereas RGC death …

SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in
the injured and diseased nervous system. While SARM1 activation and enzyme function are …

Glaucoma is a heterogeneous group of chronic neurodegenerative disorders characterized
by a relatively selective, progressive damage to the retinal ganglion cells (RGCs) and their …

In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Glaucoma, a leading cause of blindness in the world, can be challenging to diagnose
because symptoms often appear at late stage of the disease, and challenging to treat …

When the protein or calcium homeostasis of the endoplasmic reticulum (ER) is adversely
altered, cells experience ER stress that leads to various diseases including …

Axonal degeneration is a key and early pathological feature in traumatic and
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …

White matter degeneration is an important pathophysiological event of the central nervous
system that is collectively characterized by demyelination, oligodendrocyte loss, axonal …