Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

After years of in-depth research on immune checkpoints, therapeutic reversal of immune-
exhaustion with immune checkpoint inhibitors (ICPIs) has been shown to be effective in …

Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

Evasion of immune surveillance is an accepted hallmark of tumor progression. The
production of immune suppressive mediators by tumor cells is one of the major mechanisms …

In clinical practice, we noticed that triple negative breast cancer (TNBC) patients had higher
shear-wave elasticity (SWE) stiffness than non-TNBC patients and a higher α-SMA …

Galectins are a family of ß-galactoside-binding proteins that play a variety of roles in normal
physiology. In cancer, their expression levels are typically elevated and often associated …

Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years,
increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and …

Galectin-1 (Gal-1) is a secretory lectin with pro-tumor activities and is associated strongly
with hepatocellular carcinoma (HCC) development. Although Gal-1 is a well-known soluble …

Among all the biological entities involved in the immune response, galectins, a family of
glycan-binding proteins, have been described as key in immune cell homeostasis and …

Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited
treatment options. Developing new therapies is therefore crucial to address patient needs …