Mitochondrial electron transport chain, ROS generation and uncoupling

RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

Reactive oxygen species and calcium signals in skeletal muscle: a crosstalk involved in both normal signaling and disease

A Espinosa, C Henríquez-Olguín, E Jaimovich - Cell Calcium, 2016 - Elsevier
Abstract Reactive Oxygen Species (ROS) have been profusely studied as agents of potential
damage to living cells and they have been related to a number of pathological processes …

MITOL/MARCH5 determines the susceptibility of cardiomyocytes to doxorubicin-induced ferroptosis by regulating GSH homeostasis

H Kitakata, J Endo, H Matsushima, S Yamamoto… - Journal of molecular and …, 2021 - Elsevier
Abstract MITOL/MARCH5 is an E3 ubiquitin ligase that plays a crucial role in the control of
mitochondrial quality and function. However, the significance of MITOL in cardiomyocytes …

Gut mucosal proteins and bacteriome are shaped by the saturation index of dietary lipids

N Abulizi, C Quin, K Brown, YK Chan, SK Gill… - Nutrients, 2019 - mdpi.com
The dynamics of the tripartite relationship between the host, gut bacteria and diet in the gut
is relatively unknown. An imbalance between harmful and protective gut bacteria, termed …

Lactobacillus rhamnosus GG and Oat Beta‐Glucan Regulated Fatty Acid Profiles along the Gut‐Liver‐Brain Axis of Mice Fed with High Fat Diet and Demonstrated …

YF Yau, H El‐Nezami, JM Galano… - Molecular Nutrition & …, 2020 - Wiley Online Library
Scope This study takes a novel approach to investigate the anti‐inflammatory and
antioxidant effects of prebiotic oat beta‐glucan (OAT) and the probiotic Lactobacillus …

[HTML][HTML] α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat …

K Sztolsztener, K Hodun, A Chabowski - Biochimica et Biophysica Acta …, 2022 - Elsevier
Lipid mediators derived from arachidonic acid (AA) are implicated with the occurrence of
inflammation and oxidative stress. The current knowledge of AA metabolism focuses on …

The crosstalk between cardiac lipotoxicity and mitochondrial oxidative stress in the cardiac alterations in diet-induced obesity in rats

S Jiménez-González, G Marín-Royo, R Jurado-López… - Cells, 2020 - mdpi.com
The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac
alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD …

High-fat diet induced an oxidative stress in white adipose tissue and disturbed plasma transition metals in rat: prevention by grape seed and skin extract

K Charradi, S Elkahoui, F Limam, E Aouani - The journal of physiological …, 2013 - Springer
Obesity is a public health problem characterized by increased accumulation of fat into
adipose tissues leading to oxidative stress, dyslipidemia, and chronic inflammatory status …

[HTML][HTML] CD38 deficiency protects heart from high fat diet-induced oxidative stress via activating Sirt3/FOXO3 pathway

LF Wang, CC Huang, YF Xiao, XH Guan… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Previous studies showed that CD38 deficiency protected heart from
ischemia/reperfusion injury and high fat diet (HFD)-induced obesity in mice. However, the …

The interaction between mitochondrial oxidative stress and gut microbiota in the cardiometabolic consequences in diet-induced obese rats

A Ortega-Hernández, E Martínez-Martínez… - Antioxidants, 2020 - mdpi.com
Background: The objective of this study is to determine the role of mitochondrial oxidative
stress in the dysbiosis associated with a high fat diet in rats. In addition, the impact of gut …