Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …

Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

Vascular aging affects multiple organ systems, including the brain, where it can lead to
vascular dementia. However, a concrete understanding of how aging specifically affects the …

Abstract Apolipoprotein E4 (ApoE4), the strongest genetic risk factor for sporadic Alzheimer's
disease, is also a risk factor for microvascular pathologies leading to cognitive impairment …

Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …

Arteriolosclerosis is common in older brains and related to cognitive and motor impairment.
We compared the severity of arteriolosclerosis and its associations with cerebrovascular …

Worldwide, around 50 million people live with dementia, and this number is projected to
triple by 2050. It has been estimated that 20% of all dementia cases have a predominant …

Vascular cognitive impairment (VCI) traditionally encompasses a variety of cerebrovascular
pathologies that contribute to varying levels of cognitive impairment, ranging from subtle to …